When faced with imprecise knowledge, a scientist will be inclined to improve it, yet an engineer will routinely accept it. Might predictions be wrong by as much as 10 percent, and for poorly understood reasons? The reasons may pose a difficult scientific puzzle, yet an engineer might see no problem at all. Add a 50 percent margin of safety, and move on.
Safety margins are standard parts of design, and imprecise knowledge is but one of many reasons.
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PolyMth - Product Leadership 